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2023, № 106

UDC: 619:616.993.192
GSNTI: 68.41.55

Synthesis and antiprotozoal activity of 2-aminomethyl derivatives benzimidazole

Benzimidazole is a heterocyclic molecule commonly used as a building block in organic synthesis. Benzimidazole, also known as 1H-benzimidazole, benzoglyoxaline, or 1,3-benzothiazole, is a bicyclic compound having a benzene ring fused to a five-membered imidazole that contains two nitrogen atoms [8,15]. Benzimidazoles are formed as a result of the condensation reaction from 1, 2-phenylenediamine with carboxaldehyde and carboxylic acids [10]. Numerous studies have found that they have low toxicity and are highly effective against many pathogenic organisms. The scientific literature mentions that this heterocyclic ring system has been found in natural compounds and is also widely used for the synthesis of numerous drug compounds. They are of great scientific and practical importance for drug development. Numerous clinically approved drugs have been developed based on benzimidazole. Over the years, benzimidazole derivatives with a variety of pharmacological activities have been registered, including: ridinilazole (antibacterial agent), ilaprazol (anti-ulcer drug) and many others. Syntheses in the series of benzimidazole derivatives lead many researchers to the discovery of a large number of biologically active compounds, which expands the possibilities of finding drugs for many diseases. It is expected that many new pharmacological agents containing benzimidazole derivatives as active substances will be available in the near future. In this article, we describe the biologically active aminomethyl derivatives of benzimidazole, methods for their synthesis, and the results of studying their antiprotozoal activity.
Keywords: Aminomethyl derivatives of benzimidazole, synthesis, protozoa, antiprotozoal activity.
DOI: 10.21515/1999-1703-106-357-362

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Authors:

1. Zubenko Alexander Alexandrovich, DSc in Biology, North-Caucasus Zonal Scientific Research Veterinary Institute - Branch of the FSBSI FRARC.
2. Divaeva Lyudmila Nikolaevna, Phd in chemical, Research Institute of Physical and Organic Chemistry of the Southern Federal University.
3. Fetisov Leonid Nikolaevich, PhD in Veterinary, North-Caucasus Zonal Scientific Research Veterinary Institute - Branch of the FSBSI FRARC.
4. Svyatogorova Alexandra Evgenievna, PhD in Agriculture, North-Caucasus Zonal Scientific Research Veterinary Institute - Branch of the FSBSI FRARC.
5. Avagyan Helen Nverovna, Laboratory researcher, North-Caucasus Zonal Scientific Research Veterinary Institute - Branch of the FSBSI FRARC.