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2023, № 104

UDC: 619.616.98:579
GSNTI: 68.41.39

Studying the acute toxicity parameters of the drug for veterinary use of Gabitabs

The study of acute toxicity of the drug for veterinary use Gabitabs was carried out on Wistar rats. Gabitabs was administered to rats once intragastrically, after dissolving the dosage form in sterile water for injection. In the first (tentative) experiment, doses of gabapentin were used from 3433 mg/kg to 22500 mg/kg, in the second (expanded) experiment from 6048 mg/kg to 30720 mg/kg. Throughout the experiment, the animals were under constant clinical observation: attention was paid to behavior, appetite, signs of intoxication, and mortality. Integral indicators (body weight and temperature) were measured on the 0th, 7th and 14th day after the drug administration. It was established that a single intragastric administration of the drug Gabitabs in the studied dosages does not cause a lethal effect in laboratory rats; it is not possible to calculate LD50. Based on the results of the studies performed, it can be concluded that Gabitabs, when administered at a dose of more than 5000 mg/kg, does not cause death, does not have a significant negative effect on the animal body, which makes it possible to classify the drug as a low-hazard substance.
Keywords: Gabapentin, acute toxicity, rat, body weight, lethal dose.
DOI: 10.21515/1999-1703-104-181-184

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Authors:

1. Kostyanko Nikolay Olegovich, postgraduate student, Federal State Budgetary Educational Institution of Higher Education “I.T. Trubilin Kuban State Agrarian University”.
2. Shantyz Azamat Khazretovich, DSc in Veterinary, associate professor, Federal State Budgetary Educational Institution of Higher Education “I.T. Trubilin Kuban State Agrarian University”.
3. Marchenko Evgeny Yurievich, PhD in Veterinary, Federal State Budgetary Educational Institution of Higher Education “I.T. Trubilin Kuban State Agrarian University”.
4. Petrova Olga Vladislavovna, PhD in Veterinary, pharmacovigilance specialist, LLC "Apicenna".
5. Sajthanov Elman Olegovich, PhD in Biology, associate professor, Federal State Budgetary Educational Institution of Higher Education "P.A. Kostychev Ryazan Agrotechnological University".