<<<  Back

2022, № 101

UDC: 631.95
GSNTI: 68.39.37

Plants metabolites of phenolic nature as new generation phytobiotics

Secondary metabolites are chemical compounds synthesized in plants that play an insignificant role in life processes and do not play a direct role in normal metabolism and plant development, but often play an ecological role, i.e. as attractants of pollinators and chemical means of protection against microbes, insects and predators. Some medicinal plants, due to their secondary metabolites, acquire a number of biological and therapeutic properties. Secondary metabolites are classified into three chemically distinct groups: terpenes, phenolic compounds, and nitrogen-containing compounds. Phenolic compounds isolated from plants can be used to fight microorganisms resistant to a variety of drugs, but their mechanisms of action must be carefully characterized before they can be rationally used as antibacterial agents. Currently, consumer demand for safe animal feed is growing, which creates problems for animal scientists and, thus, there is interest in the use of natural feed additives. Most of the plant extract did not exhibit anti-nutritional properties in animal diets. For example, a high concentration of condensed tannins from plant extracts in animal feed can accelerate protein digestion. Whereas a higher body weight with improved health status was recorded in chickens treated with hydrolyzable tannins. This is because hydrolyzable tannic acid extracted from wood was enriched with polyphenolic compounds. The purpose of the review study was to assess the current state of mechanistic studies of plant phenolic antibacterial compounds and to emphasize the feasibility of their use as potential natural feed additives and phytobiotics in the diets of farm animals.
Keywords: Phenolic compounds, metabolites, plant extracts, phytobiotics, flavonoids.
DOI: 10.21515/1999-1703-101-223-231

References:

1. Abdel-Wareth, AAA. Effects of thyme and oregano on growth performance of broilers from 4 to 42 days of age and on microbial counts in crop, small intestine and caecum of 42-day-old broilers / AAA. Abdel-Wareth, S. Kehraus, F. Hippenstiel, K. H. Südekum // Anim Feed Sci Technol. - 2012. -178(3):198-202.
2. Abu Hafsa, S. H. Effect of dietary polyphenol-rich grape seed ongrowth performance, antioxidant capacity and ileal microflora in broilerchicks / S. H. Abu Hafsa, S. A. Ibrahim // J Anim Physiol Anim Nutri. - 2018. - 102(1):268-75.
3. Aljumaah, M. R. Effects of phytobiotic feed additives on growth traits, blood biochemistry, and meat characteristics of broiler chickens exposed to Salmonella typhimurium / M. R. Aljumaah, G. M. Suliman, A. A. Abdullatif, A. M. Abudabos // Poult Sci. - 2020. - 99:5744-51. - doi: 10.1016/j.psj.2020.07.033.
4. Allaoua, M. Journal of Applied Microbiology. - 2017. - 1162-1171.
5. Amin, M. U. Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus. BMC Complement / M. U. Amin, M. Khurram, B. Khattak, J. Khan // Altern. Med. - 2015. - 15:59. - DOI: 10.1186/s12906-015-0580-0.
6. Arsi, K. The efficacy of the natural plant extracts, thymol and carvacrol against Campylobacter colonization in broiler chickens / K. Arsi, A. M. Donoghue, K. Venkitanarayanan, A. Kollanoor-Johny, A. C. Fanatico, P. J. Blore // J Food Saf. - 2014. - 34(4):321325.
7. Bieger, J. Tissue distribution of quercetin in pigs after long-term dietary supplementation /j. Bieger, R. Cermak, R. Blank //j. Nutr. - 2008. - 138:14171420. - DOI: 10.1093/jn/138.8.1417.
8. Borges, A. Insights on antimicrobial resistance, biofilms and the use of phytochemicals as new antimicrobial agents / A. Borges, M. J. Saavedra, M. Simões // Curr. Med. Chem. - 2015. - V. 22. - 2590-2614. - DOI: 10.2174/ 0929867322666150530210522.
9. Bozkurt, M.Comparative evaluation of dietary supplementation with mannan oligosaccharide and oregano essential oil in forced molted and fully fed laying hens between 82 and 106 weeks of age / M. Bozkurt, E. Bintaş, S. Kırkan, H. Akşit, K. Küçükyılmaz, G. Erbaş // Poult Sci. - 2016. - 95(11):2576-2591.
10. Bozkurt, M. An update on approaches to controlling coccidia in poultry using botanical extracts / M. Bozkurt, I. Giannenas, K. Kucukyilmaz, E. Christaki, P. Florou-Paneri // Br Poult Sci. - 2013 - 54:713-727.
11. Bozkurt, M. Chapter 12-Application of aromatic plants and their extracts in diets of turkeys / M. Bozkurt, A. E. Tüzün // Feed Additives. London: Academic Press - 2020 - P. 205-206.
12. Castrica, M. Total phenolic content and antioxidant capacity of agri-food waste and by-products / M. Castrica, R. Rebucci, C. Giromini, M. Tretola, D. Cattaneo, A. Baldi // Ital J Anim Sci - 2019 -18(1):336-341.
13. Christaki, E. Chapter 2-Innovative uses of aromatic plants as natural supplements in nutrition / E. Christaki, I. Giannenas, E. Bonos, P. Florou-Paneri // Feed Additives. London: Academic Press - 2020 - P. 19-34.
14. Cushnie, T. P. T. Recent advances in understanding the antibacterial properties of flavonoids / T. P. T. Cushnie, A. J. Lamb // Int. J. Antimicrob - 2011. - 38, 99-107. - DOI: 10.1016/j.ijantimicag.2011.02.014.
15. Duskaev, G. K. Assessment of (In vitro) toxicity of quorum-sensing inhibitor molecules of Quercus cortex / G. K. Duskaev, D. G. Deryabin, I. F. Karimov, S. V. Notova // Journal of Pharmaceutical Sciences and Research, 2018. - 10(1), - P. 91-95.
16. Duskaev, G. Effects of Bacillus cereus and coumarin on growth performance, blood biochemical parameters, and meat quality in broilers / G. Duskaev, Sh. Rakhmatullin, O. Kvan // Veterinary World - 2020. - 13(11) - 2484-2492. - DOI 10.14202/VETWORLD.2020.2484-2492.
17. Franz, C. M. Chapter 3-Herbs and aromatic plants as feed additives: Aspects of composition, safety, and registration rules / C. M. Franz, KHC. Baser, I. Hahn-Ramssl // Feed Additives. London: Academic Press - 2020 - P. 35-56.
18. Gaur, S. Effect of oregano essential oil and carvacrol on Cryptosporidium parvum infectivity in HCT-8 cells / S. Gaur, T. B. Kuhlenschmidt, M. S. Kuhlenschmidt, J. E. Andrade // Parasitol Int. - 2018. - 67:170-175.
19. Gessner, D. K. Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals / D. K. Gessner, R. Ringseis, K. Eder // J Anim Physiol Anim Nutr. - 2017 - 101:605-628. doi: 10.1111/jpn.12579.
20. Gheisar, M. M. Phytobiotics in poultry and swine nutrition - a review / M. M. Gheisar, I. H. Kim // Ital J Anim Sci. - 2017 - 17:92-99.
21. Govaris, A. Dietary supplementation of oregano essential oil and tocopheryl acetate on microbial growth and lipid oxidation of Turkey breast fillets during storage / A. Govaris, E. Botsoglou, P. Florou-Paneri, A. Moutas, G. Papageorgiou // Int J Poult Sci. - 2005. - 4:969-975.
22. Guo, Y. Protocatechuic acid (PCA) induced a better antiviral effect by immune enhancement in SPF chickens / Y. Guo, Q. Zhang, Z. Zuo, J. Chu, H. Xiao, M. T. Javed, C. He // Microb. Pathog. - 2018. - 114, 233-238.
23. Gyawali, R. Natural products as antimicrobial agents / R. Gyawali, S. A. Ibrahim // Food Contro. - 46 - 2014. - 412-429. doi: 10.1016/j.foodcont.2014.05.047.
24. Hajati, H. The effect of grape seed extract and vitamin C feed supplements carcass characteristics, gut morphology and ileal microflora in broiler chickens exposed to chronic heat stress / H. Hajati, A. Hassanabadi, A. Golian, H. Nassiri-Moghaddam, M. Nassiri, R. Safari // Iranian J Applied Anim Sci. - 2015. - 5:155-165.
25. Hashemipour, H. Effect of thymol andcarvacrol feed supplementation on performance, antioxidant enzymeactivities, fatty acid composition, digestive enzyme activities, and immuneresponse in broiler chickens / H. Hashemipour, H. Kermanshahi, A. Golian, T. Veldkamp // Poult Sci. - 2013. - 92(8):2059-2069.
26. Jin, L. Z. Application of aromatic plants and their extracts in diets of broiler chickens / L. Z. Jin, Y. Dersjant-Li, I. Giannenas // Feed Additives. London: Academic Press. - 2020. - P. 159-185.
27. Kikusato, M. Effects of plant-derived isoquinoline alkaloids on growth performance and intestinal function of broiler chickens under heat stress / M. Kikusato, G. Xue, A. Pastor, T. A. Niewold, M. Toyomizu // Poult Sci. - 2021. - 100:957-963. doi: 10.1016/j.psj.2020.11.050.
28. Kikusato, M. Phytobiotics to improve health and production of broiler chickens: functions beyond the antioxidant activity / M. Kikusato // Anim Biosci. - 2021. - 34(3):345-353. doi: 10.5713/ab.20.0842. Epub 2021 Feb 14. PMID: 33705621; PMCID: PMC7961201.
29. Kim, D. K. Dietary Curcuma longa enhances resistance against Eimeria maxima and Eimeria tenella infections in chickens / D. K. Kim, H. S. Lillehoj, S. H. Lee, S. I. Jang, E. P. Lillehoj, D. Bravo // Poult Sci. - 2013. - 92:2635-2643. - doi: 10.3382/ps.2013-03095.
30. Kvan, O. Changes in the content of chemical elements in the muscle tissue of broilers on the background of plant extract and tetracyclines / O. Kvan, G. Duskaev, Sh. Rakhmatullin, D. Kosyan // International Journal of Environmental Science and Development - 2019. - 10 (12). - P. 419-423. - DOI 10.18178/ijesd.2019.10.12.1209.
31. Lee, M. T. Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals - a review / M. T. Lee, W. C. Lin, B. Yu, T. T. Lee // Asian-Australas J Anim Sci. - 2017. - 30:299-308. - DOI: 10.5713/ajas.16.0438.
32. Lim, A. Plant phenols as antibiotic boosters: in vitro interaction of olive leaf phenols with ampicillin / A. Lim, N. Subhan, J. A. Jazayeri, G. John, T. Vanniasinkam, H. K. Obied // Phyther. Res. - 2016. - 30, 503-509. - doi: 10.1002/ptr.5562.
33. Liu, H. Effects of hydrolysable tannins as zinc oxide substitutes on antioxidant status, immune function, intestinal morphology, and digestive enzyme activities in weaned piglets / H. Liu, J. Hu, S. Mahfuz, X. // Piao Animals. - 2020. - 10(5):757.
34. Liu, H. W. Effects of chestnut tannins on intestinal morphology, barrier function, proinflammatory cytokine expression, microflora and antioxidant capacity in heat stressed broilers / H. W. Liu, K. Li, J. S. Zhao, W. Deng // J Anim Physiol Anim Nutr. - 2018. - 102:717-726.
35. Liu, S. Effects of oral administration of different dosages of carvacrol essential oils on intestinal barrier function in broilers / S. Liu, M. Song, W. Yun, J. Lee, C. Lee, W. Kwak. // J Anim Physiol Anim Nutr. - 2018. - 102(5):1257-1265.
36. Long, S. Effects of Forsythia suspense extract as an antibiotics substitute on growth performance, nutrient digestibility, serum antioxidant capacity, fecal Escherichia coli concentration and intestinal morphology of weaned piglets / S. Long, L. Liu, S. Liu, S. Mahfuz, X. Piao // Animals. - 2019. - 9:729.
37. Mahfuz, S. Dietary inclusion of mushroom (Flammulina velutipes) stem waste on growth performance, antibody response, immune status, and serum cholesterol in broiler chickens / S. Mahfuz, T. He, S. Liu, D. Wu, S. Long, X. S. Piao // Animals. - 2019. - 9:692.
38. Manach, C. Polyphenols: food sources and bioavailability / С. Manach, A. Scalbert, C. Morand, C. Rémés, L. Jiménez // Am J Clin Nutr. - 2004. - 79:727-747. doi: 10.1093/ajcn/79.5.727.
39. Manach, C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies / C. Manach, G. Williamson, C. Morand, A. Scalbert, C. Rémésy // Am J Clin Nutr. - 2005. - 81:230S-242S. doi: 10.1093/ajcn/ 81.1.230S.
40. Martel, J. Phytochemicals as prebiotics and biological stress inducers /J. Martel, D. M. Ojcius, Y. F. Ko, J. d. Young // Trends Biochem Sci. - 2020. - 45:462-471. doi: 10.1016/j.tibs.2020. 02.008.
41. Pashtetsky, V. Use of phytobiotics in animal husbandry and poultry / V. Pashtetsky, P. Ostapchuk, T. Kuevda, D. zubochenko, S. Yemelianov, V. Uppe // E3S Web of Conferences. - 2020. - 02002. - Р. 1-9.
42. Possas, A. Application of predictive models to assess the influence of thyme essential oil on Salmonella enteritidis behaviour during shelf life of ready-to-eat turkey products / A. Possas, G. D. Posada-Izquierdo, F. Pérez-Rodríguez, A. Valero, R. M. García-Gimeno, MCT. Duarte // Int J Food Microbiol. - 2017. - 240:40-46.
43. Qureshi, S. Beneficial uses of dandelion herb (Taraxacum officinale) in poultry nutrition / S. Qureshi, S. Adil, M. E. Abd El-Hack, M. Alagawany, M. R. Farag // World’s Poult Sci J. - 2017. - 73:591-602.
44. Rupasinghe, H. V. Absorption and tissue distribution of dietary quercetin and quercetin glycosides of apple skin in broiler chickens / H. V.Rupasinghe, C. M. Ronalds, B. Rathgeber, R. A. Robinson // J Sci Food Agric. - 2010. - 90:1172-1178. - DOI: 10.1002/jsfa.3944.
45. Shanker, K. Determination of bioactive nitrile glycoside(s) in drumstick (Moringa oleifera) by reverse phase HPLC /K. Shanker, M. M. Gupta, S. K. Srivastava, D. U. Bawankule, A. Pal, P. S. Khanuja // Food Chem. - 2007 - 105:376-382.
46. Shimao, R. Effects of low-dose oleuropein diet supplementation on the oxidative status of skeletal muscles and plasma hormonal concentration of growing broiler chickens / R. Shimao, H. Muroi, K. Furukawa, M. Toyomizu, M. Kikusato // Br Poult Sci. - 2019 - 60:784-9. - DOI: 10.1080/00071668.2019.1662886.
47. Spencer, JPE. Metabolism of tea flavonoids in the gastrointestinal tract / JPE. Spencer // J Nutr. - 2003 - 133:3255S-3261S. - DOI: 10.1093/jn/133.10.3255S.
48. Starcevic, K. Production performance, meat composition and oxidative susceptibility inbroiler chicken fed with different phenolic compounds / K. Starcevic, L. Krstulović, D. Brozić, M. MaurićM, Z. Stojević, Z. Mikulec // J Sci Food Agric. - 2015. - 95(6):1172-1178.
49. Tsuchiya, H. Membrane interactions of phytochemicals as their molecular mechanism applicable to the discovery of drug leads from plants / H. Tsuchiya // Molecules 20 - 2015. 18923--18966. - DOI: 10.3390/molecules201018923.
50. Viveros, A. Effects of dietary polyphenol-rich grape products on intestinal microflora and gut morphology in broiler chicks / A. Viveros, S. Chamorro, M. Pizarro, I. Arija, C. Centeno, A. Brenes // Poult Sci. - 2011. - 90:566-578.
51. Wagle, B. R. Carvacrol attenuates Campylobacter jejuni colonization factors and proteome critical for persistence in the chicken gut / B. R. Wagle, A. M. Donoghue, S. Shrestha, I. Upadhyaya, K. Arsi, A. Gupt // Poult Sci. - 2020. - 99(9):4566-4577.
52. Williamson, G. The bioavailability, transport, and bioactivity of dietary flavonoids: a review from a historical perspective / G. Williamson, C. D. Kay, A. Crozier // Compr Rev Food Sci Food Saf. - 2018. - 7:1054-1012. doi: 10.1111/1541-4337.12351.
53. Yang, X. Effects of encapsulated organic acids and essential oils on intestinal barrier, microbial count, and bacterial metabolites in broiler chickens / X. Yang, Y. Liu, F. Yan, C. Yan, X. Yang // Poult Sci. - 2019. - 98(7). - 2858-65.
54. Zhang, S. The dietary combination of essential oils and organic acids reduces Salmonella enteritidis in challenged chicks / S. Zhang, Y. R. Shen, S. Wu, Y. Q. Xiao, Q. He, S. R. Shi // Poult Sci. - 2019. - 98(12). - 6349-6355.

Authors:

1. Kvan Olga Vilorievna, PhD in Biology, assistent professor, Federal State Budgetary Scientific Institution "Federal Scientific Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences".
2. Duskaev Galimzhan Kalikhanovich, DSc in Biology, assistent professor, Federal State Budgetary Scientific Institution "Federal Scientific Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences".
3. Gvozdikova Anastasia Mikhailovna, PhD in Biology, senior researcher, Federal State Budgetary Scientific Institution "Federal Scientific Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences".
4. Kartekenov Kanat Sharipovich, PhD in Biology, senior researcher, Federal State Budgetary Scientific Institution "Federal Scientific Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences".