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2020, № 87

UDC: 619. 615.035.1
GSNTI: 68.41.33, 68.41.37, 68.41.43

Efficacy of antibacterial preparation kolistin in studying pharmacological properties

The results of research work to study the therapeutic effectiveness of a medicinal preparation for veterinary use containing 6 million IU of colistin as an active substance in pigs bacterial infections are presented. In total, 30 piglets of the LYD breed (3 breed hybrid) were used in the experiment, at the age of 35-42 days. The basis for research in the experimental farm was morbidity and mortality of piglets after weaning (age 5-6 weeks) with similar clinical signs: a disorder of gastrointestinal function (decrease or lack of appetite, diarrhea), impaired nervous activity (arousal, muscle tremor). In fallen animals, a pathological study recorded cataralic inflammation of the gastric mucosa, cataralic enterocolitis, congestive hyperemia and swelling of the pulmonary tissue, enlargement of the spleen. The test regimen was to use the drug Colibak to animals orally, in a group with water for drinking at the following doses of 120--160 mg/10 kg of animal body weight, for 3-5 days. In the control group of animals, a comparative preparation was used - Colimixol 6 million IU in the dose of 120-160 mg/10 kg of body weight inside, similar to the scheme for using the drug Kolibak in the experimental group. It has been found that the therapeutic effectiveness of medicinal preparation for veterinary application containing 6 mln IU sulfate as an active substance of colistin in case of mixed gastrointestinal infection of piglets during growth in dose 120-160 mg/10 kg of body weight is 100%. The preparation in the specified dose provides rapid recovery of the diseased piglets, does not have a negative effect on the body and is well tolerated by animals.
Keywords: Colistin sulfate, therapy, pigs, antibacterial drug, infection, dose.
DOI: 10.21515/1999-1703-87-104-109

References:

1. Астахова, Д. А. Гемодинамические расстройства у поросят при колибактериозе и их коррекция / Д. А. Астахова // Автореферат дисс. - Новочеркасск, 2010. - 16 с.
2. Востроилова, Г. А. Определение оптимальной терапевтической дозы тилоколина для свиней / Г. А. Востроилова, В. И. Беляев, С. Н. Кабицкий // Актуальные вопросы ветеринарной биологии. - 2010. - № 2 (6). - С. 22.
3. Гафаров, Х. З. Инфекционные болезни свиней и современные средства их диагностики, лечения и профилактики / Х. З. Гаффаров, Е. А. Романов. - М.: Аквариум-Принт, 2004. - 192 с.
4. Дельцов, А. А. Современное состояние фармацевтического рынка лекарственных средств для ветеринарного применения в странах ЕАЭС / А. А. Дельцов, И. В. Косова // Вопросы обеспечения качества лекарственных средств. - 2020. - № 1 (27). - С. 61-67.
5. Дельцов, А. А. Ретроспективный анализ отечественного рынка ветеринарных препаратов / А. А. Дельцов, И. В. Косова // Фармация. - 2019. - Т. 68. - № 8. - С. 40-43.
6. Ковзов, В. В. Сравнительная эффективность применения препаратов «Амоксикол вк» и «Тилокол вк» при лечении телят с болезнями органов дыхания и поросят с диарейным синдромом / В. В. Ковзов // Ученые записки УО ВГАВМ, 2017. - Т. 53, вып. 1. - С. 59.
7. Кретова, С. Н. Эффективность применения сукцината натрия для лечения поросят с симптомами отечной болезни / С. Н. Кретова // Материалы Международной науч.-практ конференции, посвященной 80- летию Пермской ГСХА. Инновационному развитию АПК - научное обоснование. - Пермь, 2010. - С. 25-28.
8. Шантыз, А. Х. Терапевтическая эффективность антибактериального лекарственного препарата нозигептид 1% при клостридиозе поросят / А. Х. Шантыз, И. С. Коба, Л. А. Хахов, Л. М. Кашковская // Ветеринария и кормление. - 2019. - № 7. - С. 8-10.

Authors:

1. Koba Igor Sergeevich, DSc in Veterinary, Professor, Federal State Budgetary Educational Institution of Higher Education "Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Scriabin".
2. Pchelnikov Alexander Vladimirovich, Phd in Veterinary, associate professor, Federal State Budgetary Educational Institution of Higher Education "Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Scriabin".
3. Shantyz Azamat Khazretovich, DSc in Veterinary, Professor, Federal State Budgetary Educational Institution of Higher Education “I.T. Trubilin Kuban State Agrarian University”.
4. Luneva Albina Vladimirovna, Phd in Biology, associate professor, Federal State Budgetary Educational Institution of Higher Education “I.T. Trubilin Kuban State Agrarian University”.
5. Kashkovskaya Lyudmila Mikhailovna, Phd in Biology, Associate Professor, Federal State Budgetary Educational Institution of Higher Education "Saratov State Agrarian University named after N.I. Vavilov".
6. Dorozhkin Vasily Ivanovich, DSc in Veterinary, Professor, Academician of the Russian Academy of Sciences, Federal State Budgetary Scientific Institution "All-Russian Scientific Research Institute of Veterinary Sanitation, Hygiene and Ecology".